To reduce the development of drug-resistant bacteria and maintain the effectiveness of Meropenem for Injection, USP, and other antibacterial drugs, Meropenem for Injection, USP should only be used to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Complicated Intra-abdominal Infections
Bacterial Meningitis
Complicated Skin and Skin Structure Infections
| Table 1 Recommended Meropenem for Injection, USP Dosage Schedule for Pediatric Patients 3 Months of Age and Older with Normal Renal Function |
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|---|---|---|---|
| Type of Infection | Dose (mg/kg) | Maximum Dose Dosing Interval | |
| Complicated skin and skin structure infections | 10 | 500mg - every 8 hours | |
| Complicated intra-abdominal infections | 20 | 1gram - every 8 hours | |
| Meningitis | 40 | 2grams - every 8 hours | |
| Table 2 Recommended Meropenem for Injection, USP Dosage Schedule for Pediatric Patients Less than 3 Months of Age with Complicated Intra-abdominal Infections and Normal Renal Function |
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|---|---|---|---|
| Age group | Dose(mg/kg) | Dose interval | |
| Infants less than 32 weeks GA and PNA 2 weeks and older | 20 | Every 8 hours | |
| Infants 32 weeks and older GA and PNA less than 2 weeks | 20 | Every 8 hours | |
| Infants 32 weeks and older GA and PNA 2 weeks and older | 30 | Every 8 hours | |
| There is no experience in pediatric patients with renal impairment. | |||
| Table 3 Recommended Meropenem for Injection, USP Dosage Schedule for Adult Patients with Renal Impairment |
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|---|---|---|---|
| Creatinine Clearance (mL/min) | Dose (dependent on the type of infection) | Dosing Interval | |
| Greater than 50 | Recommended dose (500 mg cSSSI and 1 gram Intra-abdominal) | Every 8 hours | |
| 26 to 50 | Recommended dose | Every 12 hours | |
| 10 to 25 | One-half recommended dose | Every 12 hours | |
| Less than 10 | One-half recommended dose | Every 24 hours | |
| (There is inadequate information regarding the use of Meropenem for Injection, USP in patients on hemodialysis or peritoneal dialysis.) | |||